Therapeutic gases in liquid form are attractive and have the potential for significant advantages over inhaled gas in terms of safety, dosing accuracy, and ease of use.
Parkinson’s Disease (chronic use) PREclinical
Sickle Cell Disease (chronic use) Cardioprotection from Doxorubicin Toxicity (sub-chronic use) Kidney Transplant (acute use)
(Instilled CO) Our GLASS platform also has the potential to address other hematologic, neurodegenerative, cardiovascular, immune and oncology indications. Hillhurst has been awarded multiple grants from the NIH (NHLBI, NIDDK, NINDS, NIGMS) to advance its efforts to treat hematologic, CNS, cardiovascular, and kidney diseases.
Other Research Areas
Our GLASS platform enables the oral delivery of low dose carbon monoxide. This delivery method addresses key tissues impacted by Sickle Cell Disease, Parkinson’s Disease, and Doxorubicin Toxicity during cancer treatment
Sickle Cell Disease: Clinical studies by others indicate both safety and efficacy of low dose carbon monoxide in sickle cell disease, but up until now it hasn’t been possible to safely and effectively deliver carbon monoxide to sickle cell disease patients. HBI-002 provides a unique dual mechanism of action: reducing inflammation and cell death via the heme oxygenase pathway; and blocking the polymerization of hemoglobin. An IND is in place for HBI-002 in sickle cell disease, with a Phase 1 clinical trial in healthy volunteers planned in 2021/2.
Parkinson’s Disease: It has long been known that smoking cigarettes, a source of carbon monoxide, is associated with protection from Parkinson’s disease. Our preclinical studies showing that HBI-002 is protective in Parkinson’s disease mice and rats indicating that the carbon monoxide in cigarette smoke, via the heme oxygenase pathway, may be the cause of this counterintuitive finding.
Cardioprotection from Doxorubicin Toxicity: Doxorubicin is a critical cancer drug, but it can cause substantial heart toxicity. Preclinical research demonstrates that low dose CO protects against damage to the heart from doxorubicin via the heme oxygenase cytoprotective pathway.
Kidney Transplant: Past clinical studies suggest a protective effect of low dose CO in preventing delayed graft function in kidney transplant. Our investigational intravenous dosage form is designed for intraoperative use, such as during transplant surgery.
Acute Pain: The analgesic (anti-pain) properties of the therapeutic gas nitrous oxide (N2O) are well known. With our GLASS platform, we are developing an oral nitrous oxide therapeutic for the management of acute pain.